The CoR delegation is composed of twelve representatives and twenty-four from the Regions, six from the Departments and six from the Municipalities. Most Regions have liaison offices in Brussels.

Many Regions cooperate with other EU Regions, either on a bilateral basis or through European associations of Regions. Regions cooperate with various organisations such as the Council of European Municipalities and Regions (CEMR) and the Assembly of European Regions (AER). ADF and French Departments cooperate with other EU intermediate authorities, either on a bilateral basis or through the European Confederation of Intermediate Authorities (CEPLI).