Szabolcs-Szatmár-Bereg County, Transcarpathia County and Kisvárda set up Tisza EGTC in 2015. It was the first grouping in Europe that had been formed by the border areas of an EU Member State (Hungary) and a non-EU country (Ukraine).

The seat of the EGTC is in Kisvárda, Hungary, where its director is based, and its partner office is in Uzhhorod, Ukraine, where the deputy director takes care of office management. The grouping is an economically autonomous, non-profit organisation with legal personality. The general objective of Tisza EGTC is to foster cross-border cooperation between its members in order to strengthen economic, social and territorial cohesion. The task of the grouping is to generate and implement projects and programmes launched in the cross-border cooperation area to achieve the above objectives. In 2017, the cohesion study and integrated development strategy of the EGTC were published, setting out its main priorities.

Based on the goals contained in the strategy, several small-scale tenders have been implemented in recent years, and in 2017, after two years of successful operation, the grouping submitted two proposals under the HUSKROUA ENI Cross-border Cooperation Programme, both of which were suggested by the Monitoring Committee. The main focus of the grouping is environmental protection. 

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